Endothelial p53 Deletion Improves Angiogenesis and Prevents Cardiac Fibrosis and Heart Failure Induced by Pressure Overload in Mice

BACKGROUND: Cardiac dysfunction developing in response to chronic pressure overload is associated with apoptotic cell death and myocardial vessel rarefaction. We examined whether deletion of tumor suppressor p53 in endothelial cells may prevent the transition from cardiac hypertrophy to heart failur...

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Dades bibliogràfiques
Publicat a:J Am Heart Assoc
Autors principals: Gogiraju, Rajinikanth, Xu, Xingbo, Bochenek, Magdalena L., Steinbrecher, Julia H., Lehnart, Stephan E., Wenzel, Philip, Kessel, Michael, Zeisberg, Elisabeth M., Dobbelstein, Matthias, Schäfer, Katrin
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2015
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4345879/
https://ncbi.nlm.nih.gov/pubmed/25713289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.115.001770
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