Cardiac Energy Dependence on Glucose Increases Metabolites Related to Glutathione and Activates Metabolic Genes Controlled by Mechanistic Target of Rapamycin

BACKGROUND: Long chain acyl‐CoA synthetases (ACSL) catalyze long‐chain fatty acids (FA) conversion to acyl‐CoAs. Temporal ACSL1 inactivation in mouse hearts (Acsl1(H−/−)) impaired FA oxidation and dramatically increased glucose uptake, glucose oxidation, and mTOR activation, resulting in cardiac hyp...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Schisler, Jonathan C., Grevengoed, Trisha J., Pascual, Florencia, Cooper, Daniel E., Ellis, Jessica M., Paul, David S., Willis, Monte S., Patterson, Cam, Jia, Wei, Coleman, Rosalind A.
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4345858/
https://ncbi.nlm.nih.gov/pubmed/25713290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.114.001136
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