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Brain 5-HT deficiency increases stress vulnerability and impairs antidepressant responses following psychosocial stress

Brain serotonin (5-HT) deficiency and exposure to psychosocial stress have both been implicated in the etiology of depression and anxiety disorders, but whether 5-HT deficiency influences susceptibility to depression- and anxiety-like phenotypes induced by psychosocial stress has not been formally e...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Sachs, Benjamin D., Ni, Jason R., Caron, Marc G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4345581/
https://ncbi.nlm.nih.gov/pubmed/25675490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1416866112
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