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PNA binding to the non-template DNA strand interferes with transcription, suggesting a blockage mechanism mediated by R-loop formation

Peptide Nucleic Acids (PNAs) are artificial DNA mimics with superior nucleic acid binding capabilities. T7 RNA polymerase transcription upon encountering PNA bound to the non-template DNA strand was studied in vitro. A characteristic pattern of blockage signals was observed, extending downstream fro...

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Bibliografiske detaljer
Udgivet i:Mol Carcinog
Main Authors: Belotserkovskii, Boris P., Hanawalt, Philip C.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4345152/
https://ncbi.nlm.nih.gov/pubmed/25175074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.22209
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