Neutralization of osteopontin attenuates neutrophil migration in sepsis-induced acute lung injury

INTRODUCTION: Sepsis refers to severe systemic inflammation leading to acute lung injury (ALI) and death. Introducing novel therapies can reduce the mortality in ALI. Osteopontin (OPN), a secretory glycoprotein produced by immune reactive cells, plays a deleterious role in various inflammatory disea...

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Publicat a:Crit Care
Autors principals: Hirano, Yohei, Aziz, Monowar, Yang, Weng-Lang, Wang, Zhimin, Zhou, Mian, Ochani, Mahendar, Khader, Adam, Wang, Ping
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2015
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4345018/
https://ncbi.nlm.nih.gov/pubmed/25887405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13054-015-0782-3
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