Simultaneous stimulation of GABA and beta adrenergic receptors stabilizes isotypes of activated adenylyl cyclase heterocomplex

BACKGROUND: We investigated how the synthesis of cAMP, stimulated by isoproterenol acting through β-adrenoreceptors and Gs, is strongly amplified by simultaneous incubation with baclofen. Baclofen is an agonist of δ-aminobutyric acid type B receptors [GABA(B)], known to inhibit adenylyl cyclase via...

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Hlavní autoři: Robichon, Alain, Tinette, Sylvette, Courtial, Cédric, Pelletier, Franck
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2004
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC434497/
https://ncbi.nlm.nih.gov/pubmed/15189569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2121-5-25
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