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ATG12-ATG3 Interacts with Alix to Promote Basal Autophagic Flux and Late Endosome Function
The ubiquitin-like molecule ATG12 is required for the early steps of autophagy. Recently, we identified ATG3, the E2-like enzyme required for LC3 lipidation during autophagy, as an ATG12 conjugation target. Here, we demonstrate that cells lacking ATG12-ATG3 have impaired basal autophagic flux, accum...
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| Vydáno v: | Nat Cell Biol |
|---|---|
| Hlavní autoři: | , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4344874/ https://ncbi.nlm.nih.gov/pubmed/25686249 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3112 |
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