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ATG12 Conjugation to ATG3 Regulates Mitochondrial Homeostasis and Cell Death

ATG12, an ubiquitin-like modifier required for macroautophagy, has a single known conjugation target, another autophagy regulator called ATG5. Here, we identify ATG3 as a substrate for ATG12 conjugation. ATG3 is the E2-like enzyme necessary for ATG8/LC3 lipidation during autophagy. ATG12-ATG3 comple...

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Bibliografski detalji
Glavni autori: Radoshevich, Lilliana, Murrow, Lyndsay, Chen, Nan, Fernandez, Estefania, Roy, Srirupa, Fung, Christopher, Debnath, Jayanta
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2925044/
https://ncbi.nlm.nih.gov/pubmed/20723759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.07.018
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