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ATG12 Conjugation to ATG3 Regulates Mitochondrial Homeostasis and Cell Death
ATG12, an ubiquitin-like modifier required for macroautophagy, has a single known conjugation target, another autophagy regulator called ATG5. Here, we identify ATG3 as a substrate for ATG12 conjugation. ATG3 is the E2-like enzyme necessary for ATG8/LC3 lipidation during autophagy. ATG12-ATG3 comple...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2925044/ https://ncbi.nlm.nih.gov/pubmed/20723759 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.07.018 |
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