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Loss of Atg12, but not Atg5, in pro-opiomelanocortin neurons exacerbates diet-induced obesity
The autophagy-related proteins ATG12 and ATG5 form a covalent complex essential for autophagy. Here, we demonstrate that ATG12 has distinct functions from ATG5 in pro-opiomelanocortin (POMC)-expressing neurons. Upon high-fat diet (HFD) consumption, mice lacking Atg12 in POMC-positive neurons exhibit...
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| Publicado no: | Autophagy |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4502780/ https://ncbi.nlm.nih.gov/pubmed/25585051 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2014.998917 |
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