Loss of Atg12, but not Atg5, in pro-opiomelanocortin neurons exacerbates diet-induced obesity

The autophagy-related proteins ATG12 and ATG5 form a covalent complex essential for autophagy. Here, we demonstrate that ATG12 has distinct functions from ATG5 in pro-opiomelanocortin (POMC)-expressing neurons. Upon high-fat diet (HFD) consumption, mice lacking Atg12 in POMC-positive neurons exhibit...

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Bibliografiske detaljer
Udgivet i:Autophagy
Main Authors: Malhotra, Ritu, Warne, James P, Salas, Eduardo, Xu, Allison W, Debnath, Jayanta
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2015
Fag:
Basic Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4502780/
https://ncbi.nlm.nih.gov/pubmed/25585051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2014.998917
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