Coral-Derived Compound WA-25 Inhibits Angiogenesis by Attenuating the VEGF/VEGFR2 Signaling Pathway

Background: WA-25 (dihydroaustrasulfone alcohol, a synthetic derivative of marine compound WE-2) suppresses atherosclerosis in rats by reducing neointima formation. Because angiogenesis plays a critical role in the pathogenesis of atherosclerosis, the present study investigated the angiogenic functi...

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Udgivet i:Mar Drugs
Main Authors: Lin, Shih-Wei, Huang, Shih-Chung, Kuo, Hsiao-Mei, Chen, Chiu-Hua, Ma, Yi-Ling, Chu, Tian-Huei, Bee, Youn-Shen, Wang, E-Ming, Wu, Chang-Yi, Sung, Ping-Jyun, Wen, Zhi-Hong, Wu, Deng-Chyang, Sheu, Jyh-Horng, Tai, Ming-Hong
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4344606/
https://ncbi.nlm.nih.gov/pubmed/25668036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md13020861
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