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Sensing complex regulatory networks by conformationally controlled hairpin ribozymes
The hairpin ribozyme catalyses RNA cleavage by a mechanism utilizing its conformational flexibility during the docking of two independently folded internal loop domains A and B. Based on this mechanism, we designed hairpin ribozyme variants that can be induced or repressed by external effector oligo...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC434448/ https://ncbi.nlm.nih.gov/pubmed/15199169 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh643 |
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