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Population pharmacokinetic analysis of oxaliplatin in adults and children identifies important covariates for dosing
PURPOSE: To characterize the determinants of variability for oxaliplatin pharmacokinetics including age, renal function, and hepatic function in children and adults. METHODS: Oxaliplatin pharmacokinetic data were combined from phase I and II clinical trials: 3 pediatric trials (Peds1–3) and 2 adult...
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| Publicado no: | Cancer Chemother Pharmacol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4344382/ https://ncbi.nlm.nih.gov/pubmed/25557868 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-014-2667-6 |
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