Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway.

Normal p53 function is required for optimal arrest of cells in the G1 phase of the cell cycle following certain types of DNA damage. Loss of this cell cycle checkpoint may contribute to tumor development by increasing the number of genetic abnormalities in daughter cells following DNA damage. The MD...

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Autors principals: Chen, C Y, Oliner, J D, Zhan, Q, Fornace, A J, Vogelstein, B, Kastan, M B
Format: Artigo
Idioma:Inglês
Publicat: 1994
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC43434/
https://ncbi.nlm.nih.gov/pubmed/8146175
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