Stereochemical Evidence for the Evolution of Pyridoxal-phosphate Enzymes of Various Function from a Common Ancestor

Several pyridoxal-phosphate-dependent enzymes can convert the bound cofactor to pyridoxamine phosphate. This conversion may be an obligatory part of the normal catalytic sequence, as with transaminases, or may be an abnormal path, inactivating the enzyme. This conversion requires protonation of the...

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Bibliografische gegevens

Gepubliceerd in:	Proc Natl Acad Sci U S A
Hoofdauteurs:	Dunathan, H. C., Voet, J. G.
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	National Academy of Sciences 1974
Onderwerpen:	Biological Sciences: Biochemistry
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC434290/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4530268/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.71.10.3888
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