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Stereochemical Evidence for the Evolution of Pyridoxal-phosphate Enzymes of Various Function from a Common Ancestor

Several pyridoxal-phosphate-dependent enzymes can convert the bound cofactor to pyridoxamine phosphate. This conversion may be an obligatory part of the normal catalytic sequence, as with transaminases, or may be an abnormal path, inactivating the enzyme. This conversion requires protonation of the...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Dunathan, H. C., Voet, J. G.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 1974
Témata:
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC434290/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4530268/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.71.10.3888
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