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Stereochemical Evidence for the Evolution of Pyridoxal-phosphate Enzymes of Various Function from a Common Ancestor

Several pyridoxal-phosphate-dependent enzymes can convert the bound cofactor to pyridoxamine phosphate. This conversion may be an obligatory part of the normal catalytic sequence, as with transaminases, or may be an abnormal path, inactivating the enzyme. This conversion requires protonation of the...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Dunathan, H. C., Voet, J. G.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 1974
Sujets:
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC434290/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4530268/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.71.10.3888
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