Fluorescence Study of Domain Structure and Lipid Interaction of Human Apolipoproteins E3 and E4

Human apolipoprotein E (apoE) isoforms exhibit different conformational stabilities and lipid-binding properties that give rise to altered cholesterol metabolism among the isoforms. Using Trp-substituted mutations and site-directed fluorescence labeling, we made a comprehensive comparison of the con...

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Bibliographic Details
Published in:Biochim Biophys Acta
Main Authors: Mizuguchi, Chiharu, Hata, Mami, Dhanasekaran, Padmaja, Nickel, Margaret, Okuhira, Keiichiro, Phillips, Michael C., Lund-Katz, Sissel, Saito, Hiroyuki
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4342298/
https://ncbi.nlm.nih.gov/pubmed/25281910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2014.09.019
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