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Molecular Basis for the Differences in Lipid and Lipoprotein Binding Properties of Human Apolipoproteins E3 and E4

Human apolipoprotein (apo)E4 binds preferentially to very low density lipoproteins (VLDL) whereas apoE3 binds preferentially to high density lipoprotein (HDL), resulting in different plasma cholesterol levels with the two isoforms. To understand the molecular basis for this effect, the isolated apoE...

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Hlavní autoři: Nguyen, David, Dhanasekaran, Padmaja, Nickel, Margaret, Nakatani, Ryosuke, Saito, Hiroyuki, Phillips, Michael C., Lund-Katz, Sissel
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3025481/
https://ncbi.nlm.nih.gov/pubmed/21114327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi1017655
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