Sequestration of fatty acids in triglycerides prevents endoplasmic reticulum stress in an in vitro model of cardiomyocyte lipotoxicity

We used human cardiomyocyte-derived cells to create an in vitro model to study lipid metabolism and explored the effects of PPARγ, ACSL1 and ATGL on fatty acid-induced ER stress. Compared to oleate, palmitate treatment resulted in less intracellular accumulation of lipid droplets and more ER stress,...

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Publicado en:Biochim Biophys Acta
Autores principales: Bosma, Madeleen, Dapito, Dianne H., Drosatos-Tampakaki, Zoi, Huiping-Son, Ni, Huang, Li-Shin, Kersten, Sander, Drosatos, Konstantinos, Goldberg, Ira J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4342292/
https://ncbi.nlm.nih.gov/pubmed/25251292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2014.09.012
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