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IRF1 marks activated genes in SLE and can induce target gene expression

OBJECTIVE: IRF1 both mediates responses to type I interferons and the induction of interferons. It has been implicated in murine lupus models as a critical mediator of inflammation. A previous study of chromatin modifications in SLE patient monocytes implicated IRF1 as associated with increased hist...

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Detalhes bibliográficos
Publicado no:Arthritis Rheumatol
Main Authors: Zhang, Zhe, Shi, Lihua, Song, Li, Ephrem, Elshaddai, Petri, Michelle, Sullivan, Kathleen E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4342285/
https://ncbi.nlm.nih.gov/pubmed/25418955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.38964
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