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Probabilities of Fitness Consequences for Point Mutations Across the Human Genome

We describe a novel computational method for estimating the probability that a point mutation at each position in a genome will influence fitness. These fitness consequence (fitCons) scores serve as evolution-based measures of potential genomic function. Our approach is to cluster genomic positions...

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Bibliografiske detaljer
Udgivet i:Nat Genet
Main Authors: Gulko, Brad, Hubisz, Melissa J., Gronau, Ilan, Siepel, Adam
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4342276/
https://ncbi.nlm.nih.gov/pubmed/25599402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3196
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