PCSK9 is a critical regulator of the innate immune response and septic shock outcome

A decrease in the activity of proprotein convertase subtilisin/kexin type 9 (PCSK9) increases the amount of lowdensity lipoprotein (LDL) receptors on liver cells and, therefore, LDL clearance. The clearance of lipids from pathogens is related to endogenous lipid clearance; thus, PCSK9 may also regul...

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Gepubliceerd in:Sci Transl Med
Hoofdauteurs: Walley, Keith R., Thain, Katherine R., Russell, James A., Reilly, Muredach P., Meyer, Nuala J., Ferguson, Jane F., Christie, Jason D., Nakada, Taka-aki, Fjell, Chris D., Thair, Simone A., Cirstea, Mihai S., Boyd, John H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4342147/
https://ncbi.nlm.nih.gov/pubmed/25320235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3008782
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