Multiple associated variants increase the heritability explained for plasma lipids and coronary artery disease

BACKGROUND: Plasma lipid levels as well as coronary artery disease (CAD) have been shown to be highly heritable with estimates ranging from 40%–60%. However, top variants detected by large-scale genome-wide association studies (GWAS) explain only a fraction of the total variance in plasma lipid phen...

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Bibliografiske detaljer
Udgivet i:Circ Cardiovasc Genet
Main Authors: Tada, Hayato, Won, Hong-Hee, Melander, Olle, Yang, Jian, Peloso, Gina M, Kathiresan, Sekar
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4341828/
https://ncbi.nlm.nih.gov/pubmed/25170055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.113.000420
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