Risk prediction by genetic risk scores for coronary heart disease is independent of self-reported family history

AIMS: Genetic risk scores (GRSs) have been associated with coronary heart disease (CHD) in large studies. We asked whether expanding an established 27-variant GRS (GRS27) to a 50-variant GRS (GRS50) improved CHD prediction and whether GRSs are independent of self-reported family history of CHD. METH...

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Detalhes bibliográficos
Publicado no:Eur Heart J
Main Authors: Tada, Hayato, Melander, Olle, Louie, Judy Z., Catanese, Joseph J., Rowland, Charles M., Devlin, James J., Kathiresan, Sekar, Shiffman, Dov
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Clinical Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4744619/
https://ncbi.nlm.nih.gov/pubmed/26392438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurheartj/ehv462
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