Rethinking gene regulatory networks in light of alternative splicing, intrinsically disordered protein domains, and post-translational modifications

Models for genetic regulation and cell fate specification characteristically assume that gene regulatory networks (GRNs) are essentially deterministic and exhibit multiple stable states specifying alternative, but pre-figured cell fates. Mounting evidence shows, however, that most eukaryotic precurs...

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Detalles Bibliográficos
Publicado en:Front Cell Dev Biol
Main Authors: Niklas, Karl J., Bondos, Sarah E., Dunker, A. Keith, Newman, Stuart A.
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2015
Assuntos:
Ecology and Evolution
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4341551/
https://ncbi.nlm.nih.gov/pubmed/25767796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2015.00008
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