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Rat Hormone Sensitive Lipase Inhibition by Cyclipostins and Their Analogs
Cyclipostins are bicyclic lipophilic phosphate natural products. We report here that synthesized individual diastereomers of cyclipostins P and R have nanomolar IC(50)s toward hormone sensitive lipase (HSL). The less potent diastereomers of these compounds have 10-fold weaker IC(50)s. The monocyclic...
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| Publicado no: | Bioorg Med Chem |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4340684/ https://ncbi.nlm.nih.gov/pubmed/25678014 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.01.028 |
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