Synthesis and kinetic evaluation of Cyclophostin and Cyclipostins phosphonate analogs as selective and potent inhibitors of microbial lipases

New series of customizable diastereomeric cis- and trans-monocyclic enol-phosphonate analogs to Cyclophostin and Cyclipostins were synthesized. Their potencies and mechanisms of inhibition toward six representative lipolytic enzymes belonging to distinct lipase families were examined. With mammalian...

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Bibliografiset tiedot
Päätekijät: Point, Vanessa, Malla, Raj K., Diomande, Sadia, Martin, Benjamin P., Delorme, Vincent, Carriere, Frederic, Canaan, Stephane, Rath, Nigam P., Spilling, Christopher D., Cavalier, Jean-François
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2012
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3518039/
https://ncbi.nlm.nih.gov/pubmed/23095026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm301216x
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