Inhibition of HIV-1 infection by a unique short hairpin RNA to chemokine receptor 5 delivered into macrophages through hematopoietic progenitor cell transduction

BACKGROUND: We recently expressed a potent and noncytotoxic short hairpin (sh)RNA directed against chemokine (c-c motif) receptor 5 (CCR5) using lentiviral mediated transduction of CD34+ hematopoietic progenitor cells (HPCs) and demonstrated the stable reduction of CCR5 expression in T-lymphocytes....

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Detalhes bibliográficos
Publicado no:J Gene Med
Main Authors: Liang, Min, Kamata, Masakazu, Chen, Kevin N., Pariente, Nonia, An, Dong Sung, Chen, Irvin S. Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340654/
https://ncbi.nlm.nih.gov/pubmed/20186995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jgm.1440
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