Enzymatic synthesis of nucleobase-modified UDP-sugars: scope and limitations

Glucose-1-phosphate uridylyltransferase in conjunction with UDP-glucose pyrophosphorylase was found to catalyse the conversion of a range of 5-substituted UTP derivatives into the corresponding UDP-galactose derivatives in poor yield. Notably the 5-iodo derivative was not converted to UDP-sugar. In...

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Pubblicato in:Carbohydr Res
Autori principali: Wagstaff, Ben A., Rejzek, Martin, Pesnot, Thomas, Tedaldi, Lauren M., Caputi, Lorenzo, O’Neill, Ellis C., Benini, Stefano, Wagner, Gerd K., Field, Robert A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340641/
https://ncbi.nlm.nih.gov/pubmed/25662737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.carres.2014.12.005
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