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Clinical and cellular roles for TDP1 and TOP1 in modulating colorectal cancer response to irinotecan
Colorectal cancer (CRC) is the third most common cancer in the world. Despite surgery, up to 50% of patients relapse with incurable disease. First line chemotherapy utilises the topoisomerase 1 (TOP1) poison irinotecan, which triggers cell death by trapping TOP1 on DNA. The removal of TOP1 peptide f...
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| Publicado no: | Mol Cancer Ther |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4340569/ https://ncbi.nlm.nih.gov/pubmed/25522766 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-14-0762 |
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