Clinical and cellular roles for TDP1 and TOP1 in modulating colorectal cancer response to irinotecan

Colorectal cancer (CRC) is the third most common cancer in the world. Despite surgery, up to 50% of patients relapse with incurable disease. First line chemotherapy utilises the topoisomerase 1 (TOP1) poison irinotecan, which triggers cell death by trapping TOP1 on DNA. The removal of TOP1 peptide f...

Cur síos iomlán

Na minha lista:
Sonraí Bibleagrafaíochta
Foilsithe in:Mol Cancer Ther
Main Authors: Meisenberg, Cornelia, Gilbert, Duncan C, Chalmers, Anthony, Haley, Vikki, Gollins, Simon, Ward, Simon E., El-Khamisy, Sherif F.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2014
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340569/
https://ncbi.nlm.nih.gov/pubmed/25522766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-14-0762
Clibeanna: Cuir Clib Leis
Gan Chlibeanna, Bí ar an gcéad duine leis an taifead seo a chlibeáil!

Míreanna Comhchosúla