Chitinase 3–like 1 Suppresses Injury and Promotes Fibroproliferative Responses in Mammalian Lung Fibrosis

Epithelial injury, alternative macrophage accumulation, and fibroproliferation coexist in the lungs of patients with idiopathic pulmonary fibrosis (IPF). Chitinase 3–like 1 (CHI3L1) is a prototypic chitinase-like protein that has been retained over species and evolutionary time. However, the regulat...

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Gepubliceerd in:Sci Transl Med
Hoofdauteurs: Zhou, Yang, Peng, Hong, Sun, Huanxing, Peng, Xueyan, Tang, Chuyan, Gan, Ye, Chen, Xiaosong, Mathur, Aditi, Hu, Buqu, Slade, Martin D., Montgomery, Ruth R., Shaw, Albert C., Homer, Robert J., White, Eric S., Lee, Chang-Min, Moore, Meagan W., Gulati, Mridu, Lee, Chun Geun, Elias, Jack A., Herzog, Erica L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340473/
https://ncbi.nlm.nih.gov/pubmed/24920662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3007096
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