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Kinase Activator-Receiver Preference in ErbB Heterodimers Is Determined by Intracellular Regions and Is Not Coupled to Extracellular Asymmetry

The EGF receptor (EGFR) family comprises four homologs in humans collectively known as the ErbB or HER proteins. ErbB proteins are receptor tyrosine kinases that become activated when ligands bind to their extracellular regions and promote formation of specific homo- and heterodimers with enhanced t...

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Библиографические подробности
Опубликовано в: :J Biol Chem
Главные авторы: Ward, Matthew D., Leahy, Daniel J.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2015
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340403/
https://ncbi.nlm.nih.gov/pubmed/25468910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.612085
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