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Site-directed Mutagenesis Switching a Dimethylallyl Tryptophan Synthase to a Specific Tyrosine C(3)-Prenylating Enzyme

The tryptophan prenyltransferases FgaPT2 and 7-DMATS (7-dimethylallyl tryptophan synthase) from Aspergillus fumigatus catalyze C(4)- and C(7)-prenylation of the indole ring, respectively. 7-DMATS was found to accept l-tyrosine as substrate as well and converted it to an O-prenylated derivative. An a...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Zocher, Georg, Stec, Edyta, Stehle, Thilo
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340383/
https://ncbi.nlm.nih.gov/pubmed/25477507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.623413
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