ApoA5 knockdown improves whole-body insulin sensitivity in high-fat-fed mice by reducing ectopic lipid content

ApoA5 has a critical role in the regulation of plasma TG concentrations. In order to determine whether ApoA5 also impacts ectopic lipid deposition in liver and skeletal muscle, as well as tissue insulin sensitivity, we treated mice with an antisense oligonucleotide (ASO) to decrease hepatic expressi...

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Bibliografiske detaljer
Udgivet i:J Lipid Res
Main Authors: Camporez, João Paulo G., Kanda, Shoichi, Petersen, Max C., Jornayvaz, François R., Samuel, Varman T., Bhanot, Sanjay, Petersen, Kitt Falk, Jurczak, Michael J., Shulman, Gerald I.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Biochemistry and Molecular Biology 2015
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340301/
https://ncbi.nlm.nih.gov/pubmed/25548259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M054080
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