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Hydrophobicity of protein determinants influences the recognition of substrates by EDEM1 and EDEM2 in human cells
BACKGROUND: EDEM1 and EDEM2 are crucial regulators of the endoplasmic reticulum (ER)-associated degradation (ERAD) that extracts misfolded glycoproteins from the calnexin chaperone system. The degradation of ERAD substrates involves mannose trimming of N-linked glycans; however the precise mechanism...
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| 出版年: | BMC Cell Biol |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
BioMed Central
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4340280/ https://ncbi.nlm.nih.gov/pubmed/25655076 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12860-015-0047-7 |
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