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The effect of rare variants on inflation of the test statistics in case–control analyses

BACKGROUND: The detection of bias due to cryptic population structure is an important step in the evaluation of findings of genetic association studies. The standard method of measuring this bias in a genetic association study is to compare the observed median association test statistic to the expec...

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Bibliografiske detaljer
Udgivet i:BMC Bioinformatics
Main Authors: Pirie, Ailith, Wood, Angela, Lush, Michael, Tyrer, Jonathan, Pharoah, Paul DP
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4339749/
https://ncbi.nlm.nih.gov/pubmed/25888290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-015-0496-1
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