Tyrosine Hydroxylase Is Short-Term Regulated by the Ubiquitin-Proteasome System in PC12 Cells and Hypothalamic and Brainstem Neurons from Spontaneously Hypertensive Rats: Possible Implications in Hypertension

Aberrations in the ubiquitin-proteasome system (UPS) are implicated in the pathogenesis of various diseases. Tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamines biosynthesis, is involved in hypertension development. In this study we investigated whether UPS regulated TH turnover in...

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Publicat a:PLoS One
Autors principals: Carbajosa, Nadia A. Longo, Corradi, Gerardo, Verrilli, María A. Lopez, Guil, María J., Vatta, Marcelo S., Gironacci, Mariela M.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4339701/
https://ncbi.nlm.nih.gov/pubmed/25710381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0116597
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