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Degradation of Tyrosine Hydroxylase by the Ubiquitin-Proteasome System in the Pathogenesis of Parkinson’s Disease and Dopa-Responsive Dystonia

Nigrostriatal dopaminergic systems govern physiological functions related to locomotion, and their dysfunction leads to movement disorders, such as Parkinson’s disease and dopa-responsive dystonia (Segawa disease). Previous studies revealed that expression of the gene encoding nigrostriatal tyrosine...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Kawahata, Ichiro, Fukunaga, Kohji
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7312529/
https://ncbi.nlm.nih.gov/pubmed/32471089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21113779
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