Selective Degradation of Abnormal Proteins in Mammalian Tissue Culture Cells

The degradation rates of several missense mutants of hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8) in mouse L cells are compared to those of the wild-type enzyme. Although the rates of total protein breakdown in the mutant cell lines are identical to that of the parental L cell line, d...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Capecchi, Mario R., Capecchi, Nancy E., Hughes, Stephen H., Wahl, Geoffrey M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 1974
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Biological Sciences: Cell Biology
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC433970/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4531013/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.71.12.4732
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