GADS is Required for TCR-Mediated Calcium Influx and Cytokine Release, but not Cellular Adhesion, in Human T Cells

GRB2 related adaptor protein downstream of Shc (GADS) is a member of the GRB2 family of adaptors and is critical for TCR-induced signaling. The current model is that GADS recruits SLP-76 to the LAT complex, which facilitates the phosphorylation of SLP-76, the activation of PLC-γ1, T cell adhesion an...

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Bibliographic Details
Published in:Cell Signal
Main Authors: Bilal, Mahmood Y., Zhang, Elizabeth Y., Dinkel, Brittney, Hardy, Daimon, Yankee, Thomas M., Houtman, Jon C.D.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4339522/
https://ncbi.nlm.nih.gov/pubmed/25636200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2015.01.012
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