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The combined loss of Gads and CD127 reveals a novel function of Gads prior to TCRβ expression
The Gads adaptor protein is an essential component of the T cell signaling complex critical for T cell receptor-mediated calcium mobilization. After expression of TCRβ in T cell precursors, Gads is required for optimal Bcl-2 expression and cell survival. Similarly, the IL-7 receptor chain CD127 is a...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4162766/ https://ncbi.nlm.nih.gov/pubmed/25037454 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12026-014-8556-6 |
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