A THEMIS:SHP1 complex promotes T-cell survival

THEMIS is critical for conventional T-cell development, but its precise molecular function remains elusive. Here, we show that THEMIS constitutively associates with the phosphatases SHP1 and SHP2. This complex requires the adapter GRB2, which bridges SHP to THEMIS in a Tyr-phosphorylation-independen...

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Détails bibliographiques
Publié dans:EMBO J
Auteurs principaux: Paster, Wolfgang, Bruger, Annika M, Katsch, Kristin, Grégoire, Claude, Roncagalli, Romain, Fu, Guo, Gascoigne, Nicholas RJ, Nika, Konstantina, Cohnen, Andre, Feller, Stephan M, Simister, Philip C, Molder, Kelly C, Cordoba, Shaun-Paul, Dushek, Omer, Malissen, Bernard, Acuto, Oreste
Format: Artigo
Langue:Inglês
Publié: BlackWell Publishing Ltd 2015
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4339124/
https://ncbi.nlm.nih.gov/pubmed/25535246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201387725
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