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Joint Association Testing of Common and Rare Genetic Variants Using Hierarchical Modeling

New sequencing technologies provide an opportunity for assessing the impact of rare and common variants on complex diseases. Several methods have been developed for evaluating rare variants, many of which use weighted collapsing to combine rare variants. Some approaches require arbitrary frequency t...

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Vydáno v:Genet Epidemiol
Hlavní autoři: Cardin, Niall J., Mefford, Joel A., Witte, John S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4339046/
https://ncbi.nlm.nih.gov/pubmed/22807252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.21659
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