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Joint Association Testing of Common and Rare Genetic Variants Using Hierarchical Modeling

New sequencing technologies provide an opportunity for assessing the impact of rare and common variants on complex diseases. Several methods have been developed for evaluating rare variants, many of which use weighted collapsing to combine rare variants. Some approaches require arbitrary frequency t...

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Bibliographic Details
Published in:Genet Epidemiol
Main Authors: Cardin, Niall J., Mefford, Joel A., Witte, John S.
Format: Artigo
Language:Inglês
Published: 2012
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4339046/
https://ncbi.nlm.nih.gov/pubmed/22807252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.21659
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