Hydrophobic and Charged Residues in the C-Terminal Arm of Hepatitis C Virus RNA-Dependent RNA Polymerase Regulate Initiation and Elongation

The RNA-dependent RNA polymerase (RdRp) of hepatitis C virus (HCV) is essential for viral genome replication. Crystal structures of the HCV RdRp reveal two C-terminal features, a β-loop and a C-terminal arm, suitably located for involvement in positioning components of the initiation complex. Here w...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Cherry, Amy L., Dennis, Caitriona A., Baron, Andrew, Eisele, Leslie E., Thommes, Pia A., Jaeger, Joachim
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338901/
https://ncbi.nlm.nih.gov/pubmed/25428878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01106-14
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