The pan-inhibitor of Aurora kinases danusertib induces apoptosis and autophagy and suppresses epithelial-to-mesenchymal transition in human breast cancer cells

Danusertib (Danu) is a pan-inhibitor of Aurora kinases and a third-generation breakpoint cluster region-Abelson murine leukemia viral oncogene homolog 1 (Bcr-Abl) tyrosine kinase inhibitor, but its antitumor effect and underlying mechanisms in the treatment of human breast cancer remain elusive. Thi...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Drug Des Devel Ther
Main Authors: Li, Jin-Ping, Yang, Yin-Xue, Liu, Qi-Lun, Zhou, Zhi-Wei, Pan, Shu-Ting, He, Zhi-Xu, Zhang, Xueji, Yang, Tianxin, Pan, Si-Yuan, Duan, Wei, He, Shu-Ming, Chen, Xiao-Wu, Qiu, Jia-Xuan, Zhou, Shu-Feng
Format: Artigo
Jezik:Inglês
Izdano: Dove Medical Press 2015
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338784/
https://ncbi.nlm.nih.gov/pubmed/25733818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S74412
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