Loss of Function in Heparan Sulfate Elongation Genes EXT1 and EXT 2 Results in Improved Nitric Oxide Bioavailability and Endothelial Function

BACKGROUND: Heparanase is the major enzyme involved in degradation of endothelial heparan sulfates, which is associated with impaired endothelial nitric oxide synthesis. However, the effect of heparan sulfate chain length in relation to endothelial function and nitric oxide availability has never be...

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Bibliographic Details
Published in:J Am Heart Assoc
Main Authors: Mooij, H. L., Cabrales, P., Bernelot Moens, S. J., Xu, D., Udayappan, S. D., Tsai, A. G., van der Sande, M. A. J., de Groot, E., Intaglietta, M., Kastelein, J. J. P., Dallinga‐Thie, G. M., Esko, J. D., Stroes, E. S., Nieuwdorp, M.
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2014
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338717/
https://ncbi.nlm.nih.gov/pubmed/25468659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.114.001274
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