Systematic comparison of single-chain Fv antibody-fusion toxin constructs containing Pseudomonas Exotoxin A or saporin produced in different microbial expression systems

BACKGROUND: Antibodies raised against selected antigens over-expressed at the cell surface of malignant cells have been chemically conjugated to protein toxin domains to obtain immunotoxins (ITs) able to selectively kill cancer cells. Since latest generation immunotoxins are composed of a toxic doma...

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Publicat a:Microb Cell Fact
Autors principals: Della Cristina, Pietro, Castagna, Monica, Lombardi, Alessio, Barison, Erika, Tagliabue, Giovanni, Ceriotti, Aldo, Koutris, Ilias, Di Leandro, Luana, Giansanti, Francesco, Vago, Riccardo, Ippoliti, Rodolfo, Flavell, Sopsamorn U, Flavell, David J, Colombatti, Marco, Fabbrini, Maria Serena
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2015
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338634/
https://ncbi.nlm.nih.gov/pubmed/25889802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-015-0202-z
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