Optimization of construct design and fermentation strategy for the production of bioactive ATF-SAP, a saporin based anti-tumoral uPAR-targeted chimera

BACKGROUND: The big challenge in any anti-tumor therapeutic approach is represented by the development of drugs selectively acting on the target with limited side effects, that exploit the unique characteristics of malignant cells. The urokinase (urokinase-type plasminogen activator, uPA) and its re...

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Detalhes bibliográficos
Publicado no:Microb Cell Fact
Main Authors: Errico Provenzano, Alfredo, Posteri, Riccardo, Giansanti, Francesco, Angelucci, Francesco, Flavell, Sopsamorn U., Flavell, David J., Fabbrini, Maria Serena, Porro, Danilo, Ippoliti, Rodolfo, Ceriotti, Aldo, Branduardi, Paola, Vago, Riccardo
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5109808/
https://ncbi.nlm.nih.gov/pubmed/27842546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-016-0589-1
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