Haptoglobin attenuates hemoglobin-induced heme oxygenase-1 in renal proximal tubules cells and kidneys of a mouse model of sickle cell disease

Sickle cell disease (SCD), a hereditary hemolytic disorder is characterized by chronic hemolysis, oxidative stress, vaso-occlusion and end-organ damage. Hemolysis releases toxic cell-free hemoglobin (Hb) into circulation. Under physiologic conditions, plasma Hb binds to haptoglobin (Hp) and forms Hb...

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Publicado en:Blood Cells Mol Dis
Main Authors: Chintagari, Narendranath Reddy., Nguyen, Julia, Belcher, John D., Vercellotti, Gregory M., Alayash, Abdu I.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338572/
https://ncbi.nlm.nih.gov/pubmed/25582460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcmd.2014.12.001
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